Event Program
Thematically, the conference will be held over three days, featuring the following sessions:
- ILC Differentiation, Plasticity, and Memory
- ILC Metabolism & Systemic Homeostasis
- Evolution and Development of ILCs
- Cellular Therapies using ILCs
- ILCs in Cancer Control and Chronic Inflammation
- Crosstalk Between ILCs and the Adaptive Immune System
- ILC Tissue-Residency, Niches, and Tissue Remodeling
- Host-Microbe Interactions in Regulating ILC Function
Tuesday
June 2nd
8:15 AM – 9:15 AM: Registration and Breakfast – LSC Atrium
9:15 AM – 9:45 AM: Opening Remarks/Land Acknowledgements/Outline – LSC Room 1002
9:30 AM – 12:30 PM: Session 1 – ILC Tissue-Residency, Niches, and Tissue Remodeling
- Chairs: Joana Neves (King’s College London), Coco Chu (Tsinghua University)
- Jenny Mjösberg (Karolinska): Human ILC2, from tissue-specific regulation to therapeutic targeting
- Christoph Klose (Charité): A neuro-epithelial unit regulates intestinal homeostasis and type 2 immunity
- Jennifer Bando (Stanford): ILC3 heterogeneity in the intestinal tract
- Joana Neves (King’s College London): Human ILC3-derived TNF promotes intestinal matrix remodelling
- Sara Asif (University of Ottawa): Harnessing ILC2s for immunotherapy in ovarian cancer
- Amanda Poholek (University of Pittsburgh): Maintaining ILC2 Identity During Allergic Inflammation
- Matthew Hepworth (University of Manchester): A heparan sulfate glycocalyx supports maintenance of tissue-resident group 2 innate lymphoid cells
- Bruno Rocha (Charité): Microbiota Drives Skin Homeostasis via ILC-Derived IL-22
12:30 PM – 1:30 PM: Lunch, Social Hour, Exhibitor Viewing, Poster Viewing– LSC Atrium
1:30 PM – 3:30 PM: Session 2 – ILC Differentiation, Plasticity, and Memory
- Chairs: Avinash Bandoola (NIH/NCI), Victor Cortez (University of Pittsburgh)
- Michele Ardolino (University of Ottawa): The tiring task of studying NK cell exhaustion
- Fumio Takei (University of British Columbia): New insights into heterogeneity of ILC2s and ILC3s in mouse lungs
- Itziar Martinez-Gonzalez (Karolinska): The role of memory ILC2s in the progression of allergic diseases
- Davit Khijakadze (University of British Columbia): ILC2 plasticity in chronic allergic lung inflammation
- Jochem Bernink (Amsterdam UMC): The human airway epithelium governs homeostatic and infection-induced ILC reprogramming
3:30 PM – 4:00 PM: Coffee Break – LSC Atrium
4:00 PM – 5:00 PM: Keynote Lecture – LSC1002
- Chairs: Megan Kinzel (University of Calgary), Arthur Mortha (University of Toronto)
- Andrew McKenzie (University of Cambridge): A CRISPR view of ILC2 regulation and function
5:00 PM – 5:15 PM: Poster Pitch Competition (2min per presenter)
5:15 PM – 8:00 PM: Poster Session A and Reception – LSC Atrium
Wednesday
June 3rd
8:00 AM – 8:30 AM: Registration, breakfast and Exhibitors – LSC Atrium
8:30 AM – 8:35AM: Welcome (Nicolas Jacquelot, Nailya Ismailova) – LSC Room 1002
8:35 AM – 10:45 AM: Session 3 – ILCs in Cancer Control (1)
- Chairs: Aranzazu Cruz Adalia (Univ. Complutense of Madrid), Melanie Bruchard (CTM Dijon)
- Chiara Romagnani (Charité): Clonal memory of NK cells
- Nicolas Jacquelot (University of Calgary): Type 2 innate lymphoid cell regulation of breast cancer development and progression
- Aranzazu Cruz Adalia (University Complutense of Madrid): ILCquest: A Pan-European COST Action advancing Innate Lymphoid Cells in cancer prognosis and immunotherapy
- Katherine Zutautas (Queens University): Group 2 innate lymphoid cells regulate interleukin-33 driven inflammation in endometriosis
- Kiruthiga Raghunathan (Olivia Newton John Cancer Research Institute): Tumour educated ILC2s prime distant organ for metastasis in gastric adenocarcinoma
- Irene Mattiola (Charité): Group 3 innate lymphoid cells control endothelial cell remodelling in cancer
- Sara Trabanelli (University of Geneva): Tumor-derived steroids convert NK cells into pro-fibrotic immunosuppressive effectors in human cancer.
10:45 AM – 11:05 AM: Coffee break & Social time, Exhibitor Viewing, Poster Viewing
11:05 AM – 12:35 PM: Session 4 – ILCs in Cancer Control (2)
- Chairs: Giuseppe Sciume (Sapienza University of Rome), Shigeo Koyasu (RIKEN)
- Hye Young Kim (Seoul National University College of Medicine): From Helpers to Killers: The Expanding Anti-Tumor Arsenal of ILC2s
- Maximilian Riedel (Charité): Stromal IL-7 Shapes Tissue-Specific ILC2 Maintenance
- Xinxin Luo (Amsterdam UMC): Liver X receptor calibrates tuft cell and mucosal type 2 immunity in the intestine
- Grace Kuo (University of British Columbia): Pluripotent Stem Cell-Derived Type 2 Innate Lymphoid Cells Exhibit Potent Anti-tumor Activity Against Pancreatic Cancer Cells
- Kyle Burrows (Simon Fraser University): cMAF-dependent NCR+ectoILC3 govern the magnitude of inflammatory bowel disease
12:35 PM – 1:20 PM: Lunch, Social Hour, Poster viewing, Exhibitor Viewing
1:20 PM – 3:20 PM: Session 5 – ILC metabolism & systemic homeostasis
- Chairs: Matt Hepworth (University of Manchester), Lei Shen (Shanghai Jiao Tong University)
- Gabrielle Belz (University of Queensland): Epithelial Cartography and the Architecture of Intestinal Innate Immune Responses
- Jörg Fritz (McGill University): Lipid metabolism sustains metabolic flexibility of ILC2
- Nan Chen (University of Toronto): An intestinal IL-33-ILC2 axis regulates the sexual dimorphism in diet-induced obesity-related insulin resistance
- Takuma Misawa (RIKEN): ILC3s rewire lipid transport via the portal vein and regulate systemic metabolism
- Selma Boulenouar (Harvard): Microbiota-Metabolic Crosstalk Drives Selective Intestinal ILC3 Loss
- Cyril Seillet (Monash University): Dietary lipid sensing by ILC3s in gut homeostasis
3:20 PM – 3:40 PM: Coffee break & Social time, Exhibitor Viewing, Poster Viewing
3:40 PM – 4:40 PM: Keynote Lecture – LSC1002
- Chairs: Nailya Ismailova (McGill University), Shigeo Koyasu (RIKEN)
- Kazuyo Moro (RIKEN, University of Osaka): The two faces of amphiregulin from innate lymphoid cells
4:40 PM – 5:00 PM: Poster Pitches
5:00 PM – 6:30 PM: Poster Session B
7:00-10:00pm Gala Dinner – Museum of Anthropology
- Welcome: Fumio Takei (UBC), Elia Tait Wonjo (University of Washington), Gwilyn Timmers (Museum of Anthropology)
- Dinner will be served at 7:20pm
- Gallery tours at your discretion from 8:30pm. The Museum is open until 10:00pm
Thursday June 4th
8:00 AM – 8:30 AM: Registration, breakfast and Exhibitors – LSC Atrium
8:30 AM – 8:35 AM: Welcome (Sarah Crome, Grace Kuo) – LSC Room 1001
8:35 AM – 10:00 AM: Session 6 – Development & Differentiation of ILCs
- Chairs: Do-Hyun Kim (Hanyang University), Paula Oliver (University of Pennsylvania)
- James Di Santo (Institut Pasteur): Signals for Human ILC Differentiation and Homeostasis
- Marco Colonna (Washington University in St. Louis): Lineage Diversification and Tissue Programming in ILC1 and ILC3
- Deshan Ren (Nanjing University): Distinct ontogeny of functionally divergent human uterine natural killer cells in vivo
- Rachel Golub (Institut Pasteur, Université Paris Diderot): Neonatal ILC2s shape the vascular niche to support postnatal HSC quiescence
10:00 AM – 10:03 AM: Coffee Break
10:30AM – 12:30 PM: Session 7 – Crosstalk of ILCs and the adaptive immune system
- Chairs: Elia Tait Woijno (University of Washington), Jianhua Yu (UC Irvine)
- Arthur Mortha (University of Toronto): Interorgan trafficking of ILC2 re-sets pulmonary immunity
- Tim Halim (University of Cambridge): ILC2 regulate a fibroblast progenitor niche in the pancreas
- Nailya Ismailova (McGill University): ILC2s regulate tissue-resident adaptive immunity
- Alejandra Lopez Espinoza (University of Washington): Iron-deficiency impairs host resistance to intestinal helminth infection
- Sarah Crome (University of British Columbia): Engineered ILC2s for targeted immune regulation
12:30 PM – 1:30 PM: Lunch, Social Hour, Poster Viewing, Exhibitor Viewing
1:30 PM – 3:00 PM: Session 8 – Host-microbe crosstalk in control of ILC functions (1)
- Chairs: Sawa Shinichiro (Kyushu University), Kyle Burrows (Simon Fraser University)
- Kelly McNagny (University of British Columbia): Perinatal microbiome-ILC crosstalk in sculpting adult immune response
- Shunya Hatai (RIKEN): Microbiota-derived 11-HEPE activates the Tufted cells–ILC2 axis and protects against experimental colitis
- Roberto Ricardo-Gonzalez (UCSF): Mite-induced migratory skin-like CD103+ ILC2s establish lung residency and impact immunity
- Christine Wu (Columbia University Medical Center):The molecular basis of intestinal ILC2 recirculation
3:00 PM – 3:30 PM: Coffee break & Social time
3:30 PM – 5:00 PM: Session 8 – Host-microbe crosstalk in control of ILC functions (2)
- Chairs: Sawa Shinichiro (Kyushu University), Kyle Burrows (Simon Fraser University)
- Naoko Satoh-Takayama (RIKEN): Shaping Small Intestinal Immunity: Dietary Antigens and Innate Lymphoid Cells
- Jinfang Zhu (NIH): CRISPR-Cas9 Screen Identifies Transcription Factors that Differentially Regulate Type 2 Cytokine Expression
- Lei Shen (Shanghai Jiao Tong University): The mTORC1-NMUR1 axis drives ILC2 activation in allergic asthma
- Ari Molofksy (UCSF): Skin fungal-immune crosstalk at the hair follicle niche
5:00 PM – 6:00 PM: Keynote Lecture – LSC1001
- Chair: Grace Kuo (UBC)
- Richard Locksley (UCSF): The Enigma of Type 2 Immunity
6:00 PM – 6:30PM: Award ceremony and Closing remarks
- Michele Ardolino (University of Ottawa) & Elia Tait Wojno (University of Washington)
7:00 PM: Farewell, Social & Networking Event
- Organized by the Early Career Investigator Group
- Open to all conference participants. Free one-way shuttle to CRAFT Beer Market- False Creek Vancouver (85 W 1st Ave). Shuttle pickup outside of conference entrance at 6:45 pm
7:00 PM: Speakers Dinner
- By invitation only; in walking distance to conference venue – details will be provided on site.